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Article

Viral load and a locus on chromosome 11 affect the late clinical disease caused by Theiler's virus.

Journal of virology - 1 Oct 1999

Aubagnac S, Brahic M, Bureau J F

Abstract excerpt

Theiler's virus causes a persistent infection and a demyelinating disease of mice which is a model for multiple sclerosis. Susceptibility to viral persistence maps to several loci, including the interferon gamma locus. Inactivating the gene coding for the interferon gamma receptor makes 129/Sv mice susceptible to persistent infection and clinical disease, whereas inactivating the interferon gamma gene makes...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10482543
DOI: 10.1128/JVI.73.10.7965-7971.1999
PMCID: PMC112810

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Viral load and a locus on chromosome 11 affect the late clinical disease caused by Theiler's virus.PMID 10482543Read ↗

The genetics of the persistent infection and demyelinating disease caused by Theiler's virus.Semantic proximity Read ↗

The infection of mouse by Theiler's virus: from genetics to immunology.Semantic proximity Read ↗

Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice.Semantic proximity Read ↗

Mapping loci influencing the persistence of Theiler's virus in the murine central nervous system.Semantic proximity Read ↗

Tmevpg1, a candidate gene for the control of Theiler's virus persistence, could be implicated in the regulation of gamma interferon.Semantic proximity Read ↗

Genetics of susceptibility to Theiler's virus infection.Semantic proximity Read ↗

Interleukin 22 is a candidate gene for Tmevp3, a locus controlling Theiler's virus-induced neurological diseases.Semantic proximity Read ↗

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreadingSemantic proximity Read ↗

A genetic approach to study the pathogenesis of Theiler's virus persistent infection.Semantic proximity Read ↗

Chromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse.Semantic proximity Read ↗

CD8-deficient SJL mice display enhanced susceptibility to Theiler's virus infection and increased demyelinating pathology.Semantic proximity Read ↗

CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis.Semantic proximity Read ↗

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