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Article

The genetics of the persistent infection and demyelinating disease caused by Theiler's virus.

Annual review of microbiology - 1 Jan 2005

Brahic Michel, Bureau Jean-François, Michiels Thomas

Abstract excerpt

Theiler's virus causes a persistent and demyelinating infection of the central nervous system of the mouse, which is one of the best animal models to study multiple sclerosis. This review focuses on the mechanism of persistence. The virus infects neurons for a few weeks and then shifts to white matter, where it persists in glial cells and macrophages. Oligodendrocytes are crucial host cells, as shown by the...

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Identifiers

PMID: 16153171
DOI: 10.1146/annurev.micro.59.030804.121242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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The genetics of the persistent infection and demyelinating disease caused by Theiler's virus.PMID 16153171Read ↗

The infection of mouse by Theiler's virus: from genetics to immunology.Semantic proximity Read ↗

Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice.Semantic proximity Read ↗

The role of myelin in Theiler's virus persistence in the central nervous system.Semantic proximity Read ↗

Viral load and a locus on chromosome 11 affect the late clinical disease caused by Theiler's virus.Semantic proximity Read ↗

A protein critical for a Theiler's virus-induced immune system-mediated demyelinating disease has a cell type-specific antiapoptotic effect and a key role in virus persistence.Semantic proximity Read ↗

Interleukin 22 is a candidate gene for Tmevp3, a locus controlling Theiler's virus-induced neurological diseases.Semantic proximity Read ↗

Expression of L* protein of Theiler's murine encephalomyelitis virus in the chronic phase of infection.Semantic proximity Read ↗

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreadingSemantic proximity Read ↗

A genetic approach to study the pathogenesis of Theiler's virus persistent infection.Semantic proximity Read ↗

Mapping loci influencing the persistence of Theiler's virus in the murine central nervous system.Semantic proximity Read ↗

Tmevpg1, a candidate gene for the control of Theiler's virus persistence, could be implicated in the regulation of gamma interferon.Semantic proximity Read ↗

Viral mouse models of multiple sclerosis and epilepsy: Marked differences in neuropathogenesis following infection with two naturally occurring variants of Theiler's virus BeAn strain.Semantic proximity Read ↗

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