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Article

CD8-deficient SJL mice display enhanced susceptibility to Theiler's virus infection and increased demyelinating pathology.

Journal of neurovirology - 1 Oct 2001

Begolka W S, Haynes L M, Olson J K, Padilla J, Neville K L, Dal Canto M, Palma J, Kim B S, Miller S D

Abstract excerpt

Theiler's murine encephalomyelitis virus (TMEV) infection of the central nervous system (CNS) induces a chronic, progressive demyelinating disease in susceptible mouse strains characterized by inflammatory mononuclear infiltrates and spastic hind limb paralysis. Our lab has previously demonstrated a critical role for TMEV- and myelin-specific CD4(+) T cells in initiating and perpetuating this pathology. It has...

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Source

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Identifiers

PMID: 11582513
DOI: 10.1080/135502801753170264
PMCID: PMC7094986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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