CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis.

doi:10.1128/JVI.72.9.7320-7329.1998

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Article

CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis.

Journal of virology - 1 Sept 1998

Murray P D, Pavelko K D, Leibowitz J, Lin X, Rodriguez M

Abstract excerpt

Following intracerebral infection with Theiler's murine encephalomyelitis virus (TMEV), susceptible strains of mice (SJL and PLJ) develop virus persistence and demyelination similar to that found in human multiple sclerosis. Resistant strains of mice (C57BL/6) clear virus and do not develop demye...

Topics

Animals
Antibodies, Viral
Antigens, Viral
Brain
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Causality
Demyelinating Diseases
Disease Susceptibility
Female
Genotype
Hypersensitivity, Delayed
Male
Mice
Mice, Inbred C57BL
Multiple Sclerosis
Poliomyelitis
Theilovirus

Source

Open in PubMed Open full text

Identifiers

PMID: 9696828
DOI: 10.1128/JVI.72.9.7320-7329.1998
PMCID: PMC109956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9696828-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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