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Article

VP1 and VP2 capsid proteins of Theiler's virus are targets of H-2D-restricted cytotoxic lymphocytes in the central nervous system of B10 mice.

Virology - 1 Dec 1995

Lin X, Thiemann N R, Pease L R, Rodriguez M

Abstract excerpt

Resistance to Theiler's virus-induced demyelination maps genetically to the MHC class I D region and is associated with up-regulation of class I products and the presence of MHC-restricted virus-specific cytotoxic CD8+ T cells in the CNS. To determine the targets of the cytotoxic response, transfected C57SV (Kb, Db) cells expressing LP (including the leader peptide, VP4, VP2, and VP3 coding sequences), VP4...

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Source

Identifiers

PMID: 8525642
DOI: 10.1006/viro.1995.9951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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VP1 and VP2 capsid proteins of Theiler's virus are targets of H-2D-restricted cytotoxic lymphocytes in the central nervous system of B10 mice.PMID 8525642Read ↗

Clearance of Theiler's virus infection depends on the ability to generate a CD8 <sup>+</sup> T cell response against a single immunodominant viral peptideSemantic proximity Read ↗

The infection of mouse by Theiler's virus: from genetics to immunology.Semantic proximity Read ↗

H-2D(b-/-) mice are susceptible to persistent infection by Theiler's virus.Semantic proximity Read ↗

Conditional silencing of H-2D <sup>b</sup> class I molecule expression on dendritic cells modulates the protective and pathogenic kinetics of virus-antigen specific CD8 T cell responses during Theiler’s Virus infectionSemantic proximity Read ↗

Theiler's virus infection induces a specific cytotoxic T lymphocyte response.Semantic proximity Read ↗

The immunodominant CD8+ T cell epitope region of Theiler's virus in resistant C57BL/6 mice is critical for anti-viral immune responses, viral persistence, and binding to the host cells.Semantic proximity Read ↗

CD8-deficient SJL mice display enhanced susceptibility to Theiler's virus infection and increased demyelinating pathology.Semantic proximity Read ↗

Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice.Semantic proximity Read ↗

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epitope.Semantic proximity Read ↗

Theiler's virus-induced demyelination in mice immunosuppressed with anti-IgM and in mice expressing the xid gene.Semantic proximity Read ↗

Determinants of persistence and demyelination of the DA strain of Theiler's virus are found only in the VP1 gene.Semantic proximity Read ↗

Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice.Semantic proximity Read ↗

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