VP1 and VP2 capsid proteins of Theiler's virus are targets of H-2D-restricted cytotoxic lymphocytes in the central nervous system of B10 mice.

doi:10.1006/viro.1995.9951

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Article

VP1 and VP2 capsid proteins of Theiler's virus are targets of H-2D-restricted cytotoxic lymphocytes in the central nervous system of B10 mice.

Virology - 1 Dec 1995

Lin X, Thiemann N R, Pease L R, Rodriguez M

Abstract excerpt

Resistance to Theiler's virus-induced demyelination maps genetically to the MHC class I D region and is associated with up-regulation of class I products and the presence of MHC-restricted virus-specific cytotoxic CD8+ T cells in the CNS. To determine the targets of the cytotoxic response, transf...

Topics

Animals
Base Sequence
CD8-Positive T-Lymphocytes
Capsid
Capsid Proteins
Cell Line
Central Nervous System
DNA, Viral
H-2 Antigens
Mice
Molecular Sequence Data
Phenotype
Poliomyelitis
T-Lymphocytes, Cytotoxic
Theilovirus

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