Article
Genetic analysis of a new mouse model for non-insulin-dependent diabetes.
Genomics - 15 Jun 2001
Kim J H, Sen S, Avery C S, Simpson E, Chandler P, Nishina P M, Churchill G A, Naggert J K
Abstract excerpt
The TallyHo (TH) mouse strain is a newly established model for non-insulin-dependent diabetes mellitus (NIDDM). TH mice show obesity, hyperinsulinemia, hyperlipidemia, and male-limited hyperglycemia. A genetic dissection of the diabetes syndrome has been carried out using male backcross 1 progeny obtained from crosses between (C57BL/6J x TH)F1 and TH mice or (CAST/Ei x TH)F1 and TH mice. A genome-wide scan...
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