The TALLYHO mouse as a model of human type 2 diabetes.

doi:10.1007/978-1-62703-068-7_6

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Article

The TALLYHO mouse as a model of human type 2 diabetes.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Kim Jung Han, Saxton Arnold M

Abstract excerpt

The TALLYHO/Jng (TH) mouse is an inbred polygenic model for type 2 diabetes (T2D) with moderate obesity. Both male and female TH mice are characterized by increased body and fat pad weights, hyperleptinemia, hyperinsulinemia, and hyperlipidemia. Glucose intolerance and hyperglycemia are exhibited only in males. Reduced 2-deoxy-glucose uptake occurs in adipose tissue and skeletal muscle of male TH mice. While both...

Topics

Animals
Blood Glucose
Diabetes Mellitus, Experimental
Diabetes Mellitus, Type 2
Disease Models, Animal
Female
Humans
Hyperglycemia
Hyperinsulinism
Hyperlipidemias
Insulin Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leptin

Male

Mice

Obesity

Phenotype

Quantitative Trait Loci

Source

Open in PubMed

Identifiers

PMID: 22893402
DOI: 10.1007/978-1-62703-068-7_6

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