Whole genome sequence analysis of the TALLYHO/Jng mouse.

doi:10.1186/s12864-016-3245-6

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Article

Whole genome sequence analysis of the TALLYHO/Jng mouse.

BMC genomics - 11 Nov 2016

Denvir James, Boskovic Goran, Fan Jun, Primerano Donald A, Parkman Jacaline K, Kim Jung Han

Abstract excerpt

BACKGROUND: The TALLYHO/Jng (TH) mouse is a polygenic model for obesity and type 2 diabetes first described in the literature in 2001. The origin of the TH strain is an outbred colony of the Theiler Original strain and mice derived from this source were selectively bred for male hyperglycemia establishing an inbred strain at The Jackson Laboratory. TH mice manifest many of the disease phenotypes observed in human...

Topics

Animals
COS Cells
Chlorocebus aethiops
Diabetes Mellitus, Type 2
Disease Models, Animal
Genome
Genome-Wide Association Study
High-Throughput Nucleotide Sequencing
Humans
INDEL Mutation
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Obesity
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Sequence Analysis, DNA

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Identifiers

PMID: 27835940
DOI: 10.1186/s12864-016-3245-6
PMCID: PMC5106808

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