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Hyperglycemia and cognitive impairments anticipate the onset of an overt type 2 diabetes-like phenotype in TALLYHO/JngJ mice.

Psychoneuroendocrinology - 1 Sept 2024

Presta Martina, Zoratto Francesca, Mulder Danique, Ottomana Angela Maria, Pisa Edoardo, Arias Vásquez Alejandro, Slattery David A, Glennon Jeffrey C, Macrì Simone

Abstract excerpt

Type 2 Diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia, resulting from deficits in insulin secretion, insulin action, or both. Whilst the role of insulin in the peripheral nervous system has been ascertained in countless studies, its role in the central nervous system (CNS) is emerging only recently. Brain insulin has been lately associated with brain disorders like...

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PMID: 38896988
DOI: 10.1016/j.psyneuen.2024.107102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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