Article
A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.
Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Feb 2010
Lind Penelope A, Macgregor Stuart, Vink Jacqueline M, Pergadia Michele L, Hansell Narelle K, de Moor Marleen H M, Smit August B, Hottenga Jouke-Jan, Richter Melinda M, Heath Andrew C, Martin Nicholas G, Willemsen Gonneke, de Geus Eco J C, Vogelzangs Nicole, Penninx Brenda W, Whitfield John B, Montgomery Grant W, Boomsma Dorret I, Madden Pamela A F
Abstract excerpt
Persistent tobacco use and excessive alcohol consumption are major public health concerns worldwide. Both alcohol and nicotine dependence (AD, ND) are genetically influenced complex disorders that exhibit a high degree of comorbidity. To identify gene variants contributing to one or both of these addictions, we first conducted a pooling-based genomewide association study (GWAS) in an Australian population, using...
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