Article

HSV-1 ICP22 is a selective viral repressor of cellular RNA polymerase II-mediated transcription elongation

2021-06-08

Abstract excerpt

The Herpes Simplex Virus (HSV-1) immediate early protein ICP22 interacts with cellular proteins to inhibit host cell gene expression and promote viral gene expression. ICP22 inhibits phosphorylation of Ser2 of the RNA polymerase II (pol II) carboxyl-terminal domain (CTD) and productive elongation of pol II. Here we show that ICP22 affects elongation of pol II through both the early-elongation checkpoint and the po...

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Literature Corpus work: 1341a914-1f7a-54d9-86e5-de5205188ca2
DOI: 10.1101/2021.06.08.447513

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