Article
Interplay between human papilloma virus infection and p53 gene alterations in head and neck squamous cell carcinoma of an Indian patient population.
Journal of clinical pathology - 1 Sept 2007
Mitra S, Banerjee S, Misra C, Singh R K, Roy A, Sengupta A, Panda C K, Roychoudhury S
Abstract excerpt
AIM: To investigate the complex interplay between human papilloma virus (HPV) infection and p53 gene alteration in 92 head and neck squamous cell carcinoma (HNSCC) and 28 leukoplakia samples from eastern India. METHODS: DNA isolated from the patient samples was subjected to HPV detection, loss of heterozygosity (LOH) analysis of the chromosome 17p region harbouring p53, genotyping at the p53 codon 72 locus and...
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