Article
P53 codon 72 polymorphism, human papillomavirus infection, and their interaction to oral carcinoma susceptibility.
BMC genetics - 30 Jun 2015
Hou Jun, Gu Ying, Hou Wei, Wu Song, Lou Yin, Yang Wenyu, Zhu Ling, Hu Yukun, Sun Ming, Xue Haowei
Abstract excerpt
BACKGROUND: Tumor suppressor gene p53 plays an important role in the maintenance of the genomic integrity, and mutation in the gene may alter an individual's susceptibility to various carcinomas. P53 Arg72Pro or codon 72 polymorphism has been indicated to increase the risk of developing certain cancers such as bladder cancer and cervical cancer. Human papillomavirus (HPV) infection has been shown as a risk factor...
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