Article
p53 codon 72 polymorphism and human papillomavirus associated skin cancer.
Journal of clinical pathology - 1 Jul 2001
O'Connor D P, Kay E W, Leader M, Atkins G J, Murphy G M, Mabruk M J
Abstract excerpt
BACKGROUND/AIMS: Non-melanoma skin cancers frequently harbour multiple human papillomavirus (HPV) types. A recent report suggests that a polymorphism of the p53 tumour suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in HPV associated malignancies. This study aimed to determine the following: (1) the...
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