Article
Human papillomavirus and p53 polymorphism in codon 72 in head and neck squamous cell carcinoma.
Oncology reports - 1 Mar 2009
Hoffmann Markus, Scheunemann David, Fazel Asita, Görögh Tibor, Kahn Tomas, Gottschlich Stefan
Abstract excerpt
The impact of a polymorphism of the wild-type human tumour suppressor gene p53(wt) on carcinogenesis is subject of controversy ever since a higher susceptibility of p53 to HPV-E6 mediated degradation when encoding for Arginine at codon 72 (p53Arg) was first reported. The issue remained unclear because various studies investigating this question for different tumour entities and different geographical regions...
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