Article
P53 codon 72 polymorphism and susceptibility to development of human papilloma virus-associated cervical cancer in Indian women.
European journal of clinical investigation - 1 Dec 2002
Nagpal J K, Sahni S, Das B R
Abstract excerpt
BACKGROUND: Infection with human papilloma virus (HPV) is an important etiological factor in the development of cervical cancer and it has been proposed that individuals homozygous for Arg/Arg at codon-72 of p53 are seven times more susceptible to HPV-mediated cancer. In this study, we have analyzed the genetic predisposition of the India population to HPV infection and cervical carcinogenesis. METHODS: We...
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