Article
Truncated forms of IS911 transposase downregulate transposition.
Molecular microbiology - 1 Nov 2006
Gueguen Erwan, Rousseau Philippe, Duval-Valentin Guy, Chandler Mick
Abstract excerpt
IS911 naturally produces transposase (OrfAB) derivatives truncated at the C-terminal end (OrfAB-CTF) and devoid of the catalytic domain. A majority species, OrfAB*, was produced at higher levels at 42 degrees C than at 30 degrees C suggesting that it is at least partly responsible for the innate reduction in IS911 transposition activity at higher temperatures. An engineered equivalent of similar length,...
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