Article
Cis preference of the IS903 transposase is mediated by a combination of transposase instability and inefficient translation.
Molecular microbiology - 1 Sept 1996
Derbyshire K M, Grindley N D
Abstract excerpt
The transposase protein encoded by the insertion element IS903 belongs to an unusual class of DNA-binding proteins, termed cis-acting proteins, that act preferentially at their site of synthesis. Previous work had led us to propose that instability of the IS903 transposase was a major determinant of its cis preference. Here we describe the isolation of two classes of mutations within the transposase gene that...
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