Article
Cis preference of the IS903 transposase is mediated by a combination of transposase instability and inefficient translation.
Molecular microbiology - 1 Sept 1996
Derbyshire K M, Grindley N D
Abstract excerpt
The transposase protein encoded by the insertion element IS903 belongs to an unusual class of DNA-binding proteins, termed cis-acting proteins, that act preferentially at their site of synthesis. Previous work had led us to propose that instability of the IS903 transposase was a major determinant...
Topics
- DNA Nucleotidyltransferases
- Gene Expression Regulation
- Mutation
- Plasmids
- Protein Biosynthesis
- Transcriptional Activation
- Transposases