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Article

Evidence that the cis preference of the Tn5 transposase is caused by nonproductive multimerization.

Genes & development - 1 Oct 1994

Weinreich M D, Gasch A, Reznikoff W S

Abstract excerpt

The transposase (Tnp) of the bacterial transposon Tn5 acts 50- to 100-fold more efficiently on elements located cis to the site of its synthesis compared with those located in trans. In an effort to understand the basis for this cis preference, we have screened for Tnp mutants that exhibit increased transposition activity in a trans assay. Two mutations in the carboxyl terminus were isolated repeatedly. The EK345...

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Identifiers

PMID: 7958902
DOI: 10.1101/gad.8.19.2363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence that the cis preference of the Tn5 transposase is caused by nonproductive multimerization.PMID 7958902Read ↗

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Large-scale mutational analysis uncovers molecular mechanisms governing dual RNA functions in transposons.Semantic proximity Read ↗

A replication hijacking mechanism for Tn <i>3</i> -family replicative transpositionSemantic proximity Read ↗

A series of constitutive expression vectors to accurately measure the rate of DNA transposition and correct for auto-inhibitionSemantic proximity Read ↗

DNA sequence bias during Tn5 transposition.Semantic proximity Read ↗

A bifunctional DNA binding region in Tn5 transposase.Semantic proximity Read ↗

Transposase subunit architecture and its relationship to genome size and the rate of transposition in prokaryotes and eukaryotes.Semantic proximity Read ↗

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