Article
Multiple domains in Siz SUMO ligases contribute to substrate selectivity.
Journal of cell science - 15 Nov 2006
Reindle Alison, Belichenko Irina, Bylebyl Gwendolyn R, Chen Xiaole L, Gandhi Nishant, Johnson Erica S
Abstract excerpt
Saccharomyces cerevisiae contains two Siz/PIAS SUMO E3 ligases, Siz1 and Siz2/Nfi1, and one other known ligase, Mms21. Although ubiquitin ligases are highly substrate-specific, the degree to which SUMO ligases target distinct sets of substrates is unknown. Here we show that although Siz1 and Siz2 each have unique substrates in vivo, sumoylation of many substrates can be stimulated by either protein. Furthermore,...
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