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Article

Topoisomerase I-dependent viability loss in saccharomyces cerevisiae mutants defective in both SUMO conjugation and DNA repair.

Genetics - 1 Sept 2007

Chen Xiaole L, Silver Hannah R, Xiong Ling, Belichenko Irina, Adegite Caroline, Johnson Erica S

Abstract excerpt

Siz1 and Siz2/Nfi1 are the two Siz/PIAS SUMO E3 ligases in Saccharomyces cerevisiae. Here we show that siz1Delta siz2Delta mutants fail to grow in the absence of the homologous recombination pathway or the Fen1 ortholog RAD27. Remarkably, the growth defects of mutants such as siz1Delta siz2Delta rad52Delta are suppressed by mutations in TOP1, suggesting that these growth defects are caused by topoisomerase I...

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Share to DNA Topoisomerases, Type I

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Source

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Identifiers

PMID: 17603101
DOI: 10.1534/genetics.107.074708
PMCID: PMC2013680

Genes

TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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