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Article

Activation of the Slx5-Slx8 ubiquitin ligase by poly-small ubiquitin-like modifier conjugates.

The Journal of biological chemistry - 18 Jul 2008

Mullen Janet R, Brill Steven J

Abstract excerpt

Protein sumoylation is a regulated process that is important for the health of human and yeast cells. In budding yeast, a subset of sumoylated proteins is targeted for ubiquitination by a conserved heterodimeric ubiquitin (Ub) ligase, Slx5-Slx8, which is needed to suppress the accumulation of high molecular weight small ubiquitin-like modifier (SUMO) conjugates. Structure-function analysis indicates that the...

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Identifiers

PMID: 18499666
DOI: 10.1074/jbc.M802690200
PMCID: PMC2459270

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