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Article

Identification of a new small ubiquitin-like modifier (SUMO)-interacting motif in the E3 ligase PIASy.

The Journal of biological chemistry - 16 Jun 2017

Kaur Kawaljit, Park Hyewon, Pandey Nootan, Azuma Yoshiaki, De Guzman Roberto N

Abstract excerpt

Small ubiquitin-like modifier (SUMO) conjugation is a reversible post-translational modification process implicated in the regulation of gene transcription, DNA repair, and cell cycle. SUMOylation depends on the sequential activities of E1 activating, E2 conjugating, and E3 ligating enzymes. SUMO E3 ligases enhance transfer of SUMO from the charged E2 enzyme to the substrate. We have previously identified PIASy,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28455449
DOI: 10.1074/jbc.M117.789982
PMCID: PMC5473226

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