Article
Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.
American journal of human genetics - 1 Apr 1991
Petersen D D, McKinney C E, Ikeya K, Smith H H, Bale A E, McBride O W, Nebert D W
Abstract excerpt
The human CYP1A1 (cytochrome P1450) gene encodes an enzyme involved in the activation of procarcinogens, such as benzo[a]pyrene, to the ultimate reactive intermediate. Approximately 10% of the human population exhibit high CYP1A1 inducibility, and Kouri et al. reported that the high-inducibility phenotype might be at greater risk than low-inducibility individuals for cigarette smoke-induced bronchogenic...
Topics
- Cells, Cultured
- Cytochrome P-450 Enzyme System
- Deoxyribonuclease HpaII
- Deoxyribonucleases, Type II Site-Specific
- Exons
- Female
- Humans
- Introns
- Male
- Pedigree
- Phenotype