Article
1462V mutation in the human CYP1A1 gene: lack of correlation with either the Msp I 1.9 kb (M2) allele or CYP1A1 inducibility in a three-generation family of east Mediterranean descent.
Pharmacogenetics - 1 Feb 1994
Wedlund P J, Kimura S, Gonzalez F J, Nebert D W
Abstract excerpt
A 15-member three-generation family of Eastern Mediterranean descent was previously studied, and an association between CYP1A1 (cytochrome P1450, benzo[a]pyrene hydroxylase) inducibility and a CYP1A1 3'-polymorphism (the Msp I 1.9 kb allele) was reported (Petersen et al., Am J Hum Genet 1991:48,...
Topics
- Alleles
- Benzopyrene Hydroxylase
- Cytochrome P-450 Enzyme System
- Deoxyribonuclease HpaII
- Deoxyribonucleases, Type II Site-Specific
- Enzyme Induction
- Female
- Gene Expression Regulation, Enzymologic
- Genome, Human
- Humans
- Male
- Mediterranean Sea
- Mutation
- Pedigree
- Polymorphism, Restriction Fragment Length