Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans.

Journal of biochemistry - 1 Apr 1999

Nakajima M, Yokoi T, Mizutani M, Kinoshita M, Funayama M, Kamataki T

Abstract excerpt

A genetic polymorphism was identified in the 5'-flanking region of human CYP1A2 gene, and its effect on the transcriptional activation of the CYP1A2 gene was investigated. Nucleotide sequence analysis revealed the existence of a point mutation from guanine (wild type) to adenine (mutated type) at position -2964 in the gene. This point mutation was detected by a polymerase chain reaction-restriction fragment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caffeine
Share to Cytochrome P-450 CYP1A2
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to Point Mutation

Share to Polymorphism, Restriction Fragment Length

Share to Transcriptional Activation

Source

Identifiers

PMID: 10101295
DOI: 10.1093/oxfordjournals.jbchem.a022352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans.PMID 10101295Read ↗

Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene.Semantic proximity Read ↗

The G-113A polymorphism in CYP1A2 affects the caffeine metabolic ratio in a Chinese population.Semantic proximity Read ↗

Polymorphism of the 5'-flanking region of the CYP2E1 gene: an association study with alcoholism.Semantic proximity Read ↗

Identification of novel polymorphisms in the 5' flanking region of CYP1A2, characterization of interethnic variability, and investigation of their functional significance.Semantic proximity Read ↗

Impact of smoking, smoking cessation, and genetic polymorphisms on CYP1A2 activity and inducibility.Semantic proximity Read ↗

[Genetic polymorphism of human CYP2E1: new allels detected in exons and exon-intron junctions].Semantic proximity Read ↗

Structural and functional characterization of the 5'-flanking region of the rat and human cytochrome P450 2E1 genes: identification of a polymorphic repeat in the human gene.Semantic proximity Read ↗

Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.Semantic proximity Read ↗

Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 -163C>A polymorphism.Semantic proximity Read ↗

Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: impairment of its promoter activity.Semantic proximity Read ↗

A nicotine C-oxidase gene (CYP2A6) polymorphism important for promoter activity.Semantic proximity Read ↗

Transcriptional activity of the tandem repeat polymorphism in the 5'-flanking region of the human CYP2E1 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.