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Article

Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant.

Mutation research - 1 Apr 2007

Tournel Gilles, Cauffiez Christelle, Billaut-Laden Ingrid, Allorge Delphine, Chevalier Dany, Bonnifet Fabien, Mensier Eric, Lafitte Jean-Jacques, Lhermitte Michel, Broly Franck, Lo-Guidice Jean-Marc

Abstract excerpt

The CYP2F1 is a human cytochrome P450 that is selectively expressed in lung tissue and involved in the metabolism of various pneumotoxicants with potential carcinogenic effects. In the present study, we report the first systematic investigation of the genetic polymorphism of this enzyme. We analyzed the nucleotidic sequence of the CYP2F1 gene in DNA samples from 90 French Caucasians consisting in 44 patients with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 17327131
DOI: 10.1016/j.mrfmmm.2007.01.007

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