Regulation of plasmid R1 replication: PcnB and RNase E expedite the decay of the antisense RNA, CopA.

doi:10.1046/j.1365-2958.1997.5871953.x

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Article

Regulation of plasmid R1 replication: PcnB and RNase E expedite the decay of the antisense RNA, CopA.

Molecular microbiology - 1 Nov 1997

Söderbom F, Binnie U, Masters M, Wagner E G

Abstract excerpt

The replication frequency of plasmid R1 is controlled by an unstable antisense RNA, CopA, which, by binding to its complementary target, blocks translation of the replication rate-limiting protein RepA. Since the degree of inhibition is directly correlated with the intracellular concentration of...

Topics

Bacterial Proteins
Chromosome Mapping
DNA Replication
Endoribonucleases
Escherichia coli
Escherichia coli Proteins
Gene Dosage
Mutation
Nucleic Acid Conformation
Polynucleotide Adenylyltransferase
R Factors
RNA, Antisense
RNA, Bacterial

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