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Article

Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1-1 plasmid.

BMC microbiology - 3 Apr 2018

Yao Yuan, Enkhtsetseg Sukhbold, Odsbu Ingvild, Fan Lifei, Morigen Morigen

Abstract excerpt

BACKGROUND: The MiniR1-1 plasmid is a derivative of the R1 plasmid, a low copy cloning vector. RESULTS: Nucleotide sequencing analysis shows that the MiniR1-1 plasmid is a 6316 bp circular double-stranded DNA molecule with an oriR1 (origin for replication). The plasmid carries the repA, tap, copA and bla genes, and genes for ORF1 and ORF2. MiniR1-1 contains eight DnaA-binding sites (DnaA-boxes). DnaA-box1 is in...

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PMID: 29614952
DOI: 10.1186/s12866-018-1162-3
PMCID: PMC5883639

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