Article
Mutations in an antisense RNA, involved in the replication control of a repABC plasmid, that disrupt plasmid incompatibility and mediate plasmid speciation.
Plasmid - 1 Mar 2015
Rivera-Urbalejo América, Pérez-Oseguera Ángeles, Carreón-Rodríguez Ofelia E, Cevallos Miguel A
Abstract excerpt
The maintenance of large plasmid in a wide variety of alpha-proteobacteria depends on the repABC replication/segregation unit. The intergenic repB-repC region of these plasmids encodes a countertranscribed RNA (ctRNA) that modulates the transcription/translation rate of RepC, the initiator protein. The ctRNA acts as a strong incompatibility factor when expressed in trans. We followed a site directed mutagenesis...
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