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Article

Progression of a loop-loop complex to a four-way junction is crucial for the activity of a regulatory antisense RNA.

The EMBO journal - 1 Nov 2000

Kolb F A, Engdahl H M, Slagter-Jäger J G, Ehresmann B, Ehresmann C, Westhof E, Wagner E G, Romby P

Abstract excerpt

The antisense RNA, CopA, regulates the replication frequency of plasmid R1 through inhibition of RepA translation by rapid and specific binding to its target RNA (CopT). The stable CopA-CopT complex is characterized by a four-way junction structure and a side-by-side alignment of two long intramolecular helices. The significance of this structure for binding in vitro and control in vivo was tested by mutations in...

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Identifiers

PMID: 11060041
DOI: 10.1093/emboj/19.21.5905
PMCID: PMC305787

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Progression of a loop-loop complex to a four-way junction is crucial for the activity of a regulatory antisense RNA.PMID 11060041Read ↗

Bulged residues promote the progression of a loop-loop interaction to a stable and inhibitory antisense-target RNA complex.Semantic proximity Read ↗

Regulation of replication of plasmid R1: an analysis of the intergenic region between copA and repA.Semantic proximity Read ↗

Control of replication of plasmid R1: the intergenic region between copA and repA modulates the level of expression of repA.Semantic proximity Read ↗

Real time kinetic studies of the interaction between folded antisense and target RNAs using surface plasmon resonance.Semantic proximity Read ↗

An antisense/target RNA duplex or a strong intramolecular RNA structure 5' of a translation initiation signal blocks ribosome binding: the case of plasmid R1.Semantic proximity Read ↗

Control of replication of plasmid R1: the duplex between the antisense RNA, CopA, and its target, CopT, is processed specifically in vivo and in vitro by RNase III.Semantic proximity Read ↗

Control of ColE2 DNA replication: in vitro binding of the antisense RNA to the Rep mRNA.Semantic proximity Read ↗

Modulation of ColE1-like plasmid replication for recombinant gene expression.Semantic proximity Read ↗

Mutations in an antisense RNA, involved in the replication control of a repABC plasmid, that disrupt plasmid incompatibility and mediate plasmid speciation.Semantic proximity Read ↗

Regulation of plasmid R1 replication: PcnB and RNase E expedite the decay of the antisense RNA, CopA.Semantic proximity Read ↗

Antisense RNA regulation in prokaryotes: rapid RNA/RNA interaction facilitated by a general U-turn loop structure.Semantic proximity Read ↗

Control of ColE2 plasmid replication: regulation of Rep expression by a plasmid-coded antisense RNA.Semantic proximity Read ↗

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