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Article

Polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) are associated with susceptibility to adult acute myeloid leukemia in a Chinese population.

Cancer epidemiology - 1 Jun 2015

Huang Lulu, Deng Donghong, Peng Zhigang, Ye Fanghui, Xiao Qiang, Zhang Bing, Ye Bingbing, Mo Zengnan, Yang Xiaobo, Liu Zhenfang

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the metabolism of folate. Since acute myeloid leukemia (AML) is characterized by rapidly proliferating tissues that have a high requirement for DNA synthesis, it is possible that the presence of MTHFR polymorphisms could be linked to the multifactorial process of AML development. METHODS: We evaluated the role of MTHFR C677T and...

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Source

Identifiers

PMID: 25887077
DOI: 10.1016/j.canep.2015.02.012

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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