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Article

A genetic variant of the serine racemase gene is associated with schizophrenia.

Biological psychiatry - 15 May 2007

Morita Yukitaka, Ujike Hiroshi, Tanaka Yuji, Otani Kyohei, Kishimoto Makiko, Morio Akiko, Kotaka Tatsuya, Okahisa Yuko, Matsushita Masayuki, Morikawa Akiko, Hamase Kenji, Zaitsu Kiyoshi, Kuroda Shigetoshi

Abstract excerpt

BACKGROUND: Serine racemase (SRR) is a brain-enriched enzyme that converts L-serine to D-serine, which acts as an endogenous ligand of N-methyl D-aspartate (NMDA) receptors. Dysfunction of SRR may reduce the function of NMDA receptors and susceptibility to schizophrenia. METHODS: We genotyped three single-nucleotide polymorphisms (SNPs) of the 5' region of the SRR gene in 525 patients with schizophrenia and 524...

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Source

Identifiers

PMID: 17067558
DOI: 10.1016/j.biopsych.2006.07.025

Genes

SRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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