Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia.

Scientific reports - 5 Jul 2018

Keller Simona, Punzo Daniela, Cuomo Mariella, Affinito Ornella, Coretti Lorena, Sacchi Silvia, Florio Ermanno, Lembo Francesca, Carella Massimo, Copetti Massimiliano, Cocozza Sergio, Balu Darrick T, Errico Francesco, Usiello Alessandro, Chiariotti Lorenzo

Abstract excerpt

The spatio-temporal regulation of genes involved in the synthesis and degradation of D-serine and D-aspartate such as serine racemase (SR), D-amino acid oxidase (DAO), G72 and D-aspartate oxidase (DDO), play pivotal roles in determining the correct levels of these D-amino acids in the human brain. Here we provide a comprehensive analysis of mRNA expression and DNA methylation status of these genes in post-mortem...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Postmortem Changes

Share to Promoter Regions, Genetic

Share to RNA, Messenger

Share to Schizophrenia

Share to Serine

Source

Open in PubMed Open full text

Identifiers

PMID: 29976992
DOI: 10.1038/s41598-018-28332-x
PMCID: PMC6033866

Genes

DAO
DDO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia.PMID 29976992Read ↗

Brain Area-Specific Methylation Signatures Mark Patients With SchizophreniaSemantic proximity Read ↗

Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels.Semantic proximity Read ↗

Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.Semantic proximity Read ↗

The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.Semantic proximity Read ↗

Characterization of human DAAO variants potentially related to an increased risk of schizophrenia.Semantic proximity Read ↗

Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia.Semantic proximity Read ↗

d-Amino Acids and pLG72 in Alzheimer's Disease and Schizophrenia.Semantic proximity Read ↗

The 'golden age' of DNA methylation in neurodegenerative diseases.Semantic proximity Read ↗

Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility.Semantic proximity Read ↗

Association analysis of glycine- and serine-related genes in a Japanese population of patients with schizophrenia.Semantic proximity Read ↗

Analysis of correlation between serum D-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes.Semantic proximity Read ↗

Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.