Article
The inverse link between genetic risk for schizophrenia and migraine through NMDA (N-methyl-D-aspartate) receptor activation via D-serine.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Sept 2016
Van der Auwera Sandra, Teumer Alexander, Hertel Johannes, Homuth Georg, Völker Uwe, Lucht Michael J, Degenhardt Franziska, Schulze Thomas, Rietschel Marcella, Nöthen Markus M, John Ulrich, Nauck Matthias, Grabe Hans Jörgen
Abstract excerpt
Schizophrenia has a considerable genetic background. Epidemiological studies suggest an inverse clinical association between schizophrenia and migraine. However, it is unclear to what extent this inverse comorbidity can be explained by genetic mechanisms or by schizophrenia-related behavioral factors. For both disorders hypotheses of glutamate N-methyl-D-aspartate (NMDA) receptor dysfunction have been developed...
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