Article
Serine racemase binds to PICK1: potential relevance to schizophrenia.
Molecular psychiatry - 1 Feb 2006
Fujii K, Maeda K, Hikida T, Mustafa A K, Balkissoon R, Xia J, Yamada T, Ozeki Y, Kawahara R, Okawa M, Huganir R L, Ujike H, Snyder S H, Sawa A
Abstract excerpt
Accumulating evidence from both genetic and clinico-pharmacological studies suggests that D-serine, an endogenous coagonist to the NMDA subtype glutamate receptor, may be implicated in schizophrenia (SZ). Although an association of genes for D-serine degradation, such as D-amino acid oxidase and G72, has been reported, a role for D-serine in SZ has been unclear. In this study, we identify and characterize protein...
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