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Article

Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Sept 2007

Boks M P M, Rietkerk T, van de Beek M H, Sommer I E, de Koning T J, Kahn R S

Abstract excerpt

We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels...

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Identifiers

PMID: 17250995
DOI: 10.1016/j.euroneuro.2006.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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