Article
Neuralized promotes basal to apical transcytosis of delta in epithelial cells.
Molecular biology of the cell - 15 Jun 2010
Benhra Najate, Vignaux Françoise, Dussert Aurore, Schweisguth François, Le Borgne Roland
Abstract excerpt
Notch receptors mediate short-range signaling controlling many developmental decisions in metazoans. Activation of Notch requires the ubiquitin-dependent endocytosis of its ligand Delta. How ligand endocytosis in signal-sending cells regulates receptor activation in juxtaposed signal-receiving cells remains largely unknown. We show here that a pool of Delta localizes at the basolateral membrane of signal-sending...
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