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Article

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.

Development (Cambridge, England) - 1 Sept 2005

Pitsouli Chrysoula, Delidakis Christos

Abstract excerpt

Lateral inhibition is a pattern refining process that generates single neural precursors from a field of equipotent cells and is mediated via Notch signaling. Of the two Notch ligands Delta and Serrate, only the former was thought to participate in this process. We now show that macrochaete lateral inhibition involves both Delta and Serrate. In this context, Serrate interacts with Neuralized, a ubiquitin ligase...

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Identifiers

PMID: 16093323
DOI: 10.1242/dev.01979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.PMID 16093323Read ↗

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta.Semantic proximity Read ↗

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila.Semantic proximity Read ↗

Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila.Semantic proximity Read ↗

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.Semantic proximity Read ↗

Identification of the Mind Bomb1 Interaction Domain in Zebrafish DeltaD.Semantic proximity Read ↗

An obligatory role of mind bomb-1 in notch signaling of mammalian development.Semantic proximity Read ↗

Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila.Semantic proximity Read ↗

Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.Semantic proximity Read ↗

Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.Semantic proximity Read ↗

Mind bomb-2 is an E3 ligase for Notch ligand.Semantic proximity Read ↗

Neuralized functions as an E3 ubiquitin ligase during Drosophila development.Semantic proximity Read ↗

Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila.Semantic proximity Read ↗

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