Article
T cell receptor V beta gene bias in rheumatoid arthritis.
The Journal of clinical investigation - 1 Dec 1993
Jenkins R N, Nikaein A, Zimmermann A, Meek K, Lipsky P E
Abstract excerpt
Polymerase chain reaction (PCR) technology was employed to examine peripheral blood and synovial T cells in patients with rheumatoid arthritis (RA) for biased utilization of T cell receptor (TCR) variable region (V) genes. Oligonucleotide primers specific for individual TCR V beta gene families w...
Topics
- Adult
- Aged
- Arthritis, Rheumatoid
- Base Sequence
- DNA
- DNA Primers
- DNA, Complementary
- Female
- Genetic Variation
- Histocompatibility Testing
- Humans
- Lymphocytes
- Male
- Middle Aged
- Molecular Sequence Data
- Multigene Family
- Polymerase Chain Reaction
- Receptors, Antigen, T-Cell, alpha-beta