Article
T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR beta-chain-variable-region V beta 8.2-positive T cells are not essential for induction and course of disease.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jun 1995
Gold R, Giegerich G, Hartung H P, Toyka K V
Abstract excerpt
Predominant usage of V beta 8.2 gene segments, encoding a T-cell receptor (TCR) beta chain variable region, has been reported for pathogenic Lewis rat T cells reactive to myelin basic protein (MBP). However, up to 75% of the alpha/beta T cells in a panel of MBP-specific T-cell lines did not displ...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Base Sequence
- CD4-Positive T-Lymphocytes
- Cell Line
- Cells, Cultured
- Encephalomyelitis, Autoimmune, Experimental
- Flow Cytometry
- Gene Expression
- Genetic Variation
- Lymphocyte Depletion
- Mice