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Article

A summarization approach for Affymetrix GeneChip data using a reference training set from a large, biologically diverse database.

BMC bioinformatics - 23 Oct 2006

Katz Simon, Irizarry Rafael A, Lin Xue, Tripputi Mark, Porter Mark W

Abstract excerpt

BACKGROUND: Many of the most popular pre-processing methods for Affymetrix expression arrays, such as RMA, gcRMA, and PLIER, simultaneously analyze data across a set of predetermined arrays to improve precision of the final measures of expression. One problem associated with these algorithms is that expression measurements for a particular sample are highly dependent on the set of samples used for normalization...

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Identifiers

PMID: 17059591
DOI: 10.1186/1471-2105-7-464
PMCID: PMC1624855

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