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Article

Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data.

Nucleic acids research - 10 Nov 2005

Dai Manhong, Wang Pinglang, Boyd Andrew D, Kostov Georgi, Athey Brian, Jones Edward G, Bunney William E, Myers Richard M, Speed Terry P, Akil Huda, Watson Stanley J, Meng Fan

Abstract excerpt

Genome-wide expression profiling is a powerful tool for implicating novel gene ensembles in cellular mechanisms of health and disease. The most popular platform for genome-wide expression profiling is the Affymetrix GeneChip. However, its selection of probes relied on earlier genome and transcriptome annotation which is significantly different from current knowledge. The resultant informatics problems have a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16284200
DOI: 10.1093/nar/gni179
PMCID: PMC1283542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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