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Article

Normalization of oligonucleotide arrays based on the least-variant set of genes.

BMC bioinformatics - 5 Mar 2008

Calza Stefano, Valentini Davide, Pawitan Yudi

Abstract excerpt

BACKGROUND: It is well known that the normalization step of microarray data makes a difference in the downstream analysis. All normalization methods rely on certain assumptions, so differences in results can be traced to different sensitivities to violation of the assumptions. Illustrating the lack of robustness, in a striking spike-in experiment all existing normalization methods fail because of an imbalance...

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Identifiers

PMID: 18318917
DOI: 10.1186/1471-2105-9-140
PMCID: PMC2324100

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