Biases induced by pooling samples in microarray experiments.

Abstract excerpt

MOTIVATION: If there is insufficient RNA from the tissues under investigation from one organism, then it is common practice to pool RNA. An important question is to determine whether pooling introduces biases, which can lead to inaccurate results. In this article, we describe two biases related to pooling, from a theoretical as well as a practical point of view. RESULTS: We model and quantify the respective parts...

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