Article
Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays.
Bioinformatics (Oxford, England) - 12 Oct 2003
Jain Nitin, Thatte Jayant, Braciale Thomas, Ley Klaus, O'Connell Michael, Lee Jae K
Abstract excerpt
MOTIVATION: In microarray studies gene discovery based on fold-change values is often misleading because error variability for each gene is heterogeneous under different biological conditions and intensity ranges. Several statistical testing methods for differential gene expression have been suggested, but some of these approaches are underpowered and result in high false positive rates because within-gene...
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