Article
Transferability of tag SNPs in genetic association studies in multiple populations.
Nature genetics - 1 Nov 2006
de Bakker Paul I W, Burtt Noël P, Graham Robert R, Guiducci Candace, Yelensky Roman, Drake Jared A, Bersaglieri Todd, Penney Kathryn L, Butler Johannah, Young Stanton, Onofrio Robert C, Lyon Helen N, Stram Daniel O, Haiman Christopher A, Freedman Matthew L, Zhu Xiaofeng, Cooper Richard, Groop Leif, Kolonel Laurence N, Henderson Brian E, Daly Mark J, Hirschhorn Joel N, Altshuler David
Abstract excerpt
A general question for linkage disequilibrium-based association studies is how power to detect an association is compromised when tag SNPs are chosen from data in one population sample and then deployed in another sample. Specifically, it is important to know how well tags picked from the HapMap DNA samples capture the variation in other samples. To address this, we collected dense data uniformly across the four...
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