Article
Transferability of tag SNPs to capture common genetic variation in DNA repair genes across multiple populations.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2006
De Bakker Paul I W, Graham Robert R, Altshuler David, Henderson Brian E, Haiman Christopher A
Abstract excerpt
Genetic association studies can be made more cost-effective by exploiting linkage disequilibrium patterns between nearby single-nucleotide polymorphisms (SNPs). The International HapMap Project now offers a dense SNP map across the human genome in four population samples. One question is how well tag SNPs chosen from a resource like HapMap can capture common variation in independent disease samples. To address...
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