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Glioma Stem Cells: Signaling, Microenvironment, and Therapy

1 Jan 2016

Abstract excerpt

Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies as well as recurrent disease. GSCs are capable of self-renewal and differentiation; glioblastoma-derived GSCs are...

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PMID: 26880988
DOI: 10.1155/2016/7849890

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