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Brain tumor stem cells: The cancer stem cell hypothesis writ large

10 Aug 2010

Abstract excerpt

Brain tumors, which are typically very heterogeneous at the cellular level, appear to have a stem cell foundation. Recently, investigations from multiple groups have found that human as well as experimental mouse brain tumors contain subpopulations of cells that functionally behave as tumor stem cells, driving tumor growth and generating tumor cell progeny that form the tumor bulk, but which then lose tumorigenic...

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PMID: 20801091
DOI: 10.1016/j.molonc.2010.08.001

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